Speakers in this symposium would elucidate the molecular pathways involved in the crosstalk between vessels and nerves. The conventional view of neurovascular coupling is that neurons or astrocytes release vasodilatory factors that act directly on smooth muscle cells to increase arterial dilation and increase local blood flow. Now 1) ligand-dependent direct influence of brain vessels on neuronal behavior and 2) caveolae-dependent relaying role of endothelial cells will be presented as novel contributors to neurovascular coupling. Dysregulated neurovascular coupling may lead to subcortical vascular dementia, which lacks appropriate animal models. Here, its animal models would be introduced with neuropathologic and vascular characterization. In addition, a potential therapeutic target of arteriovenous (AV) malformations characterized by dilation of brain arteries will be introduced.
Deciphering the Role of Genome Organization in Development and Disease