Senescence or aging of endothelial cells has been implicated in progression of vascular diseases. Therefore, understanding of the molecular mechanism associated with the endothelial senescence is crucial for development of therapeutics against vascular diseases. In this session, six speakers will present recent advances in the research of endothelial regeneration and aging. Prof. Rafii has focused on stem cell biology and angiogenesis. He identified the molecular and cellular pathways involved in organ regeneration. Prof. Carmeliet has pioneered the investigation on how endothelial metabolism affects angiogenesis. Prof. Asakura has studied the molecular mechanisms controlling muscle stem cell self-renewal and differentiation, and angiogenic signals for muscle regeneration. Prof. Keshet has interested in various facets of vascular aging and its effects on physiological aging. He is going to present the relationship between VEGF signaling and healthy aging.
Promoting Healthy Againg by VEGF-Based Vascular Manipulations