Frictional fluid force from flowing blood and extracellular matrix are the critical determinants of morphogenesis and physiology in the vascular system. In this session, we have six speakers including four regular talks and two short talks, and will discuss about physiological functions of mechanotransduction and extracellular matrix in vascular system. Dr. Martin A Schwartz from Yale University, will talk about the novel mechanisms of endothelial sensing on fluid shear stress and their functions in vascular remodeling and atherosclerosis. Our second speaker, Dr. Stefan Offermanns from Max Planck Institute for Heart and Lung Research, will discuss about the regulation of endothelial phenotype by different flow patterns. Our third speaker, Dr. Hanjoong Jo from Emory University, will give us a talk about the effect of disturbed flow on transcriptional landscape and chromatin accessibility in mouse endothelial cells. Finally, Dr. Britta Trappmann from Max Planck Institute for Molecular Biomedicine will present about the regulation of angiogenic sprouting by the extracellular matrix. In addition, we will have two short talks selected from the abstracts. The first speaker of short talk, Dr. Chang-Hoon Woo from Yeungnam University will talk about a novel mechano-sensor transducing laminar flow-mediated endothelial signaling. And Dr. Elizabeth Jones from KU Leuven, the last speaker of short talk, will present about a novel mechanism of vascular shunting in embryos.
Regulation of Endothelial Phenotype by Different Flow Patterns