Cardiovascular disease remains the leading cause of death in individuals with hypertension and metabolic syndrome. Although there is increased cardiovascular disease from accelerated atherosclerosis resulting in increased incidence of ischemic heart disease and stroke, there is also an independent increase in the incidence of heart failure. The mechanisms for the increased risk of heart failure are multifactorial and include changes in mitochondrial function. Mitochondria are the established powerhouses of the cell, responsible for generating ATP via oxidative metabolism and electron transport but mitochondrial dysfunction disrupts metabolism and is thought to underlie cardiovascular disease. The session will provide a recent knowledge regarding the mechanisms for and contribution of mitochondrial dysfunction to cardiovascular diseases.
(Short Talk) TIMP3 Is a Potent Regulator of Cancer-Associated Fibroblasts-Mediated Angiogenesis in Invasive Breast Cancer.