Angiogenesis, the process which generates new vessels from pre-existing vessels, is the key to maintain vascular homeostasis and an integral process for vascular remodeling. The first session of IVBM2020 conference features six exciting presentations on diverse aspects of angiogenesis and vascular remodeling. The first speaker of the session, Dr. Bautch will present her recent findings on the unexpected role of SMAD6 as a key mediator for shear stress responses in endothelial cells. Dr. Mochizuki will report his recent finding on the contribution of endoderm to endothelial cells during angiogenesis. Dr. Gerhardt will provide novel insights on how endothelial cells integrate physical and biochemical stimulation. Dr. Jin will present the newly identified link between ALK3 and vascular homeostasis. Dr. Siekmann will report an unanticipated selectivity of PI3K in endothelial cells. Last but not least, Dr. Itoh will report how TGF-β signaling modulates tumor angiogenesis. Collectively, these presentations highlight recent conceptual advances in the field of angiogenesis.
(Short Talk) VEGF-Mediated Activation of ERK and PI3K Balances Endothelial Cell Migration and Proliferation During Angiogenesis